This paper from the Asian Development Bank (ADB) outlines the process for using Most Significant Change in evaluation. It provides a step by step process that can be followed to ensure its effective implementation.
"The Most Significant Change technique facilitates project and program improvement by focusing the direction of work away from less-valued directions toward more fully shared visions and explicitly valued directions, e.g., what do we really want to achieve and how will we produce more of it? It can also help uncover important, valued outcomes not initially specified. It delivers these benefits by creating space for stakeholders to reflect, and by facilitating dynamic dialogue." (Serrat, 2009)
Serrat, O. Asian Development Bank, (2009). The most significant change technique (January 2009 | 25). Retrieved from website: http://www.adb.org/sites/default/files/pub/2009/most-significant-change.pdf